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บทคัดย่อ

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Abstract

The objectives of the present study were to determine bacteriological cure rates and subsequent new infection rates of mild and moderate clinical mastitis cases caused by gram positive pathogens after treatment with either oxytocin or antibiotic intramammary infusion with cephapirin sodium (ToDay™, Zoetis, Thailand). A randomized controlled field trial was conducted between January and August 2014 using small-holder dairy farms in northern Thailand. Cows with clinical mastitis included in the study were randomly assigned into 1) treatment with oxytocin (OXY); 2) treatment with intramammary cephapirin sodium after milking for 2 (C2X) and 4 (C4X) consecutive times. The main isolated pathogens were Streptococcus uberis (26.4%) and other streptococci (15.6%). Clinical cure rates were 36.4%, 68.8% and 68.8% and bacteriological cure rates were 36.4%, 81.3% and 75.0% for OXY, C2X and C4X, respectively. The new intramammary infections were found at day 10 in both C2X (38.5%) and C4X (33.3%) groups, but not in OXY. In conclusion, treatment of mild and moderate clinical mastitis with cephapirin sodium has more bacteriological cure rates than treatment without antibiotics.